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Game-Changing Weight Loss Solution for Postmenopausal Women: Tirzepatide + HRT

Jul 29, 2025

Flow Wellness brings new hope to postmenopausal women struggling with weight loss. A groundbreaking study presented at ENDO 2025 shows that combining tirzepatide (Zepbound) with menopause hormone therapy (HRT) significantly enhances weight loss results.

A Powerful Combo: Tirzepatide + Hormone Replacement Therapy

Researchers from the Mayo Clinic conducted a real-world study involving 120 postmenopausal women over 18 months. Participants who used both tirzepatide and HRT outperformed those using tirzepatide alone in weight loss.

Key Results:

  • 17% total body weight loss for those using tirzepatide + HRT

  • 14% total body weight loss with tirzepatide alone

  • 45% of combination users achieved ≥ 20% body weight loss

  • Only 18% of tirzepatide-only users met that mark

These numbers speak volumes about the power of combining modern medical therapies for targeted weight management.

Why Menopause Makes Weight Loss Harder

As estrogen levels drop during menopause, many women experience:

  • Increased abdominal fat

  • Reduced muscle mass

  • Slower metabolism

  • Higher risk of heart disease and insulin resistance

These biological changes make traditional diet and exercise less effective—prompting the need for more personalized medical solutions.

The Science Behind the Breakthrough

According to Dr. Regina Castaneda, lead author of the study:

“This is the first real-world data showing that tirzepatide and menopause hormone therapy together significantly increase weight loss outcomes in postmenopausal women.”

This builds on previous findings where semaglutide (another GLP-1 medication) showed similar synergy with HRT—signaling a new frontier in hormone-informed obesity treatment.

What This Means for You

Flow Wellness is committed to evidence-based care. We understand that hormonal health and metabolism are deeply connected—and we’re here to guide you through that journey.

Our HRT & Weight Loss Program is designed specifically for postmenopausal women who want to:

  • Lose weight safely

  • Improve metabolic health

  • Regain energy and confidence

Ready to Transform Your Health?

Flow Wellness offers a combined Hormone Replacement Therapy + Weight Loss package tailored for postmenopausal women. If you’ve struggled to lose weight despite your efforts, this clinically proven combination could be the solution you’ve been waiting for.

Schedule a consultation today to find out if you’re a candidate.

This summary is based on research presented at ENDO 2025, the Endocrine Society’s annual meeting. For more wellness insights and evidence-based health information, visit theflowwellness.com.

Disclaimer: This blog post is for informational purposes only and should not be considered medical advice. Always consult with a healthcare provider for personalized medical advice. Weight loss results vary by individual and can not be guaranteed.
GLP-1 medication may only be obtained with a prescription from a licensed health care provider. If your prescriber determines GLP-1 medication is right for you, obtaining a prescription is hassle-free through Flow Wellness.
Wegovy® is a registered trademark of Novo Nordisk. Zepbound® is registered trademark of Eli Lilly. We do not claim affiliation with or endorsement by Novo Nordisk or Eli Lilly.

The Flow Wellness Difference

IV Therapy | Peptide Therapy & Prescription Supplement | Medical Weight Loss | Hormone Replacement | Ketamine Therapy

Clinic locations in Bend, Oregon (Old Mill) & Seattle, Washington (South Lake Union). Telehealth in California, Oregon, & Washington

Medical Weight Loss

Our medical weight loss programs are designed to deliver safe, sustainable results. We combine prescription medications, nutritional guidance, lifestyle coaching, and ongoing medical monitoring to help you lose weight, improve metabolic health, and maintain your results long-term.

Hormone Replacement Therapy (HRT)

We offer hormone optimization for men and women to address fatigue, mood changes, weight gain, and other symptoms of hormonal imbalance. Our bioidentical hormone replacement programs are personalized to restore optimal levels and support overall vitality.

Peptide Therapy & Prescription Supplements

Peptides are short chains of amino acids that play a vital role in cellular function and repair. At Flow Wellness, we offer personalized peptide protocols to support athletic performance, muscle recovery, and cognitive performance. Prescription supplements available for enhanced energy, hair & skin rejuvenation, and sexual health. All treatments are medically supervised for safety and results.

Ketamine Therapy for Mental Health

Flow Wellness provides IV & oral ketamine treatments in a safe, controlled, and supportive environment. This innovative treatment has shown promise for individuals struggling with depression, anxiety, PTSD, and other mental health challenges—especially when traditional therapies have been ineffective. IV treatments available at our Bend, Oregon clinic.

IV Therapy in Bend, Oregon

Our customized IV infusions deliver rapid hydration and essential nutrients directly into your bloodstream for maximum absorption. Whether you’re looking to boost your immune system, recover from illness, enhance athletic performance, or simply feel more energized, our IV therapy options are designed to meet your specific needs.

Why patients love working with us:

  • Transparent pricing and no guesswork
  • Auto-pay and referral discounts
  • Fast shipping or in-clinic pickup
  • Friendly, experienced medical providers who really care

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