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The Science Behind Ketamine for Depression & Anxiety

Sep 27, 2025

For decades, traditional antidepressants have been the standard treatment for depression and anxiety. While these medications help many, they often take weeks to work—and some people don’t respond at all. That’s where ketamine, an FDA-approved medication originally used in anesthesia, has opened a new door of hope. At Flow Wellness, we’ve seen how this innovative treatment can bring real relief to patients living with treatment-resistant depression, anxiety, and PTSD.

How Ketamine Works Differently

Most antidepressants work by adjusting levels of serotonin, dopamine, or norepinephrine in the brain. These changes can be effective but usually take weeks to months to fully develop.

Ketamine, on the other hand, works in a unique way:

  • Targets NMDA Receptors: Ketamine blocks a receptor in the brain called the N-methyl-D-aspartate (NMDA) receptor. This action leads to an increase in glutamate, the most abundant neurotransmitter in your brain.

  • Boosts Brain Plasticity: Glutamate helps form new neural connections. By stimulating this pathway, ketamine encourages your brain to “rewire” itself—making it easier to break free from rigid thought patterns of depression or anxiety.

  • Acts Rapidly: Unlike traditional medications, ketamine can begin improving mood and reducing suicidal thoughts within hours to days.

What the Research Shows

Multiple clinical studies have confirmed ketamine’s effectiveness:

  • Rapid Relief: In many patients with treatment-resistant depression, ketamine significantly reduces symptoms within 24 hours.

  • Sustained Benefits: A series of treatments, combined with ongoing wellness practices, can help extend the relief.

  • Anxiety & PTSD: Research also supports ketamine’s benefit in reducing anxiety symptoms and traumatic stress, giving patients more breathing room to heal.

These findings have transformed how clinicians approach depression that hasn’t improved with traditional therapy.

Enhancing the Benefits

While ketamine itself is powerful, pairing it with other supportive practices can maximize its impact:

  • Therapy & Counseling: Many patients find that ketamine makes it easier to engage in talk therapy by reducing emotional barriers.

  • Mindfulness & Journaling: Recording thoughts and feelings after a session can deepen insights and support long-term growth.

  • Healthy Lifestyle: Sleep, nutrition, and movement all play a role in maintaining the brain’s new connections.

Flow Wellness: Patient Safety First

At Flow Wellness, patient safety is our top priority. Every ketamine session is:

  • Administered in a comfortable, monitored environment

  • Supervised by experienced medical providers with years of infusion expertise

  • Supported with education and follow-up care to help patients integrate their experience

A New Path Forward

Depression and anxiety can make life feel like it’s standing still. Ketamine offers something different: the possibility of relief within days—not weeks. For many, it has meant the first step toward reclaiming joy, connection, and purpose.

If you or someone you love is struggling with depression, anxiety, or PTSD, Flow Wellness is here to help. Schedule a consultation with our experienced team to see if ketamine treatment may be right for you.

Disclaimer: This blog post is for informational purposes only and should not be considered medical advice. Always consult with a healthcare provider for personalized medical advice. IV & oral ketamine treatments are not FDA approved and are used off-label.

The Flow Wellness Difference

IV Therapy | Peptide Therapy & Prescription Supplement | Medical Weight Loss | Hormone Replacement | Ketamine Therapy

Clinic locations in Bend, Oregon (Old Mill) & Seattle, Washington (South Lake Union). Telehealth in California, Oregon, & Washington

Medical Weight Loss

Our medical weight loss programs are designed to deliver safe, sustainable results. We combine prescription medications, nutritional guidance, lifestyle coaching, and ongoing medical monitoring to help you lose weight, improve metabolic health, and maintain your results long-term.

Hormone Replacement Therapy (HRT)

We offer hormone optimization for men and women to address fatigue, mood changes, weight gain, and other symptoms of hormonal imbalance. Our bioidentical hormone replacement programs are personalized to restore optimal levels and support overall vitality.

Peptide Therapy & Prescription Supplements

Peptides are short chains of amino acids that play a vital role in cellular function and repair. At Flow Wellness, we offer personalized peptide protocols to support athletic performance, muscle recovery, and cognitive performance. Prescription supplements available for enhanced energy, hair & skin rejuvenation, and sexual health. All treatments are medically supervised for safety and results.

Ketamine Therapy for Mental Health

Flow Wellness provides IV & oral ketamine treatments in a safe, controlled, and supportive environment. This innovative treatment has shown promise for individuals struggling with depression, anxiety, PTSD, and other mental health challenges—especially when traditional therapies have been ineffective. IV treatments available at our Bend, Oregon clinic.

IV Therapy in Bend, Oregon

Our customized IV infusions deliver rapid hydration and essential nutrients directly into your bloodstream for maximum absorption. Whether you’re looking to boost your immune system, recover from illness, enhance athletic performance, or simply feel more energized, our IV therapy options are designed to meet your specific needs.

Why patients love working with us:

  • Transparent pricing and no guesswork
  • Auto-pay and referral discounts
  • Fast shipping or in-clinic pickup
  • Friendly, experienced medical providers who really care

Ready to Begin?

All services have a free consultation or discovery phone call. Learn more here.

If you are already working with a Flow Wellness provider, message them here. Or contact us.