At Flow Wellness, we understand that weight loss isn’t just about the number on the scale—it’s about how you feel while getting there. That’s why we take a whole-body approach to supporting our patients on GLP-1 medications. One of our most trusted allies in this journey? Vitamin B6.

Also known as pyridoxine, Vitamin B6 is a water-soluble vitamin that plays an important role in everything from mood regulation to metabolism. When combined with weight loss medications, B6 can help reduce side effects, enhance results, and support your overall well-being.

What is Vitamin B6?

Vitamin B6 is essential for numerous bodily functions, including:

• Neurotransmitter production (like serotonin and dopamine)

• Protein metabolism

• Immune system support

• Red blood cell formation

• Cognitive function and mood regulation

Unfortunately, when the body is under the stress of weight loss, or when nutrient intake is reduced due to appetite suppression, B6 levels can become suboptimal.

Why B6 Matters with GLP-1 Medications

GLP-1 medications are powerful tools for weight loss—but they also shift how your body processes food, nutrients, and energy. Here’s how Vitamin B6 can help:

1. Reduces Nausea

One of the most common side effects of GLP-1 medications is nausea—especially in the early stages of treatment. B6 is well known for its anti-nausea properties, which is why it’s often used during pregnancy or after surgeries. Taking B6 can make it easier to stay consistent with your medication and avoid disruptions to your treatment plan.

2. Supports Mood and Mental Clarity

Low B6 levels can lead to irritability, fatigue, or even mild depression. Since GLP-1 medications sometimes cause appetite changes that affect nutrient intake, supplementing with B6 helps keep your neurotransmitters balanced, supporting a positive mood and mental sharpness.

3. Aids in Protein Metabolism

Maintaining lean muscle mass is essential during weight loss, and your body needs B6 to properly metabolize the protein you eat. Ensuring you get enough B6 helps your body build and repair muscle, especially when combined with strength training.

4. Improves Tolerance to GLP-1 Side Effects

In addition to nausea, some patients report bloating or fatigue. By supporting metabolism and reducing inflammation, B6 helps improve overall tolerance to GLP-1 medications, making your weight loss journey smoother.

Research-Backed Benefits

Multiple studies have shown the benefit of B6 supplementation in clinical settings:

• May reduce symptoms of nausea and vomiting

• Supports healthy energy levels during caloric restriction

• Helps stabilize mood and reduce PMS-like symptoms

How We Offer Vitamin B6 at Flow Wellness

At Flow Wellness, we include Vitamin B6 in our compounded GLP-1 formulations and IV infusions to help patients feel better, longer. Whether you’re receiving weekly injections or ongoing IV therapy, our providers will recommend the right blend of nutrients—tailored to your body and your goals.

We also offer standalone B-complex injections for those looking for targeted nausea relief or energy support during their weight loss journey.

Injected vitamins are not intended to diagnose, treat, cure, or prevent any disease. Injected vitamins and GLP-1 medications must be obtained with a prescription by a licensed medical provider. Compounded GLP-1 medications nor injected vitamins are not reviewed by the FDA for safety, efficacy, or quality. Compounded medications are only indicated for patients when a prescribing practitioner determines that the compounded preparation produces a significant difference for their patient compared to the FDA-approved product. This blog post is for informational purposes only and should not be considered medical advice. Always consult with a healthcare provider for personalized medical advice.