If you’re taking semaglutide (Ozempic®) or tirzepatide (Mounjaro®), you might notice fatigue, brain fog, or sluggishness — even while hitting your weight-loss goals. This isn’t just in your head. Rapid weight loss, shifts in metabolism, and nutrient changes can temporarily stress your body’s energy systems.

The good news? You don’t have to sacrifice energy for results. With targeted support, your body can keep burning fat, losing weight, and staying sharp.

Why GLP-1s Can Leave You Tired

1. Rapid weight loss: Your body prioritizes essential processes like metabolism and healing over “non-essential” functions, like hair and sometimes even energy levels.

2. Nutrient gaps: Eating less or losing weight quickly can reduce levels of B12, iron, and choline, all critical for energy production and cellular function.

3. Metabolic shifts: GLP-1s change how your body uses glucose and fat, which can temporarily leave you feeling sluggish.

4. Mitochondrial stress: Your cells’ power plants — mitochondria — work overtime during rapid metabolic changes. Fatigue and brain fog are often a sign they need extra support.

GLP-1s are fantastic for weight and metabolic health — but your cells may need a boost to keep up with the pace.

Flow Wellness’ Energy Support Protocol for GLP-1 Patients

We’ve developed a lineup of science-backed supplements to restore stamina, mental clarity, and vitality while your body adapts.

Vitamin B12 — $149 per vial
1 mL SQ up to 3x/week

• Boosts energy and mental clarity

• Supports metabolism and nerve function

• Helps counteract fatigue from rapid weight loss
  Think of B12 as cellular fuel — your energy engine relies on it to run efficiently.

Lipo/MICC — $199 per vial
1 mL IM up to 3x/week

• Methionine, Inositol, and Choline support liver function and fat metabolism

• Converts stored fat into usable energy

• Maintains focus and energy during metabolic shifts
  This combination helps your body make the most of accelerated fat burning without draining your system.

Glutathione — $149 per vial
1 mL IM up to 3x/week

• Detoxifies the liver and neutralizes free radicals

• Supports immune function and brain clarity

• Promotes skin, mood, and cognitive wellness
  Glutathione protects your cells so they can focus on producing energy instead of fighting oxidative stress.

NAD+ — $249 vial / $199 troche
Vial: 100 mg SQ up to 3x/week, increase as tolerated
Troche: 1 SL daily x 30 days (300 mg each)

• Powers mitochondrial energy production

• Supports cognition, athletic recovery, and DNA repair

• Helps counteract fatigue and brain fog
  NAD+ is the spark plug for your cells — without it, energy production slows, and focus fades.

Combining NAD+ with B12 or Glutathione amplifies mitochondrial efficiency and detox support.

Synapsin — $199/month
nasal spray 1-3 times daily

Synapsin is a neuro-supportive blend designed to enhance focus, mental clarity, and memory, especially helpful for cognitive fog that sometimes occurs during rapid metabolic changes. It works synergistically with NAD+ and B12 for total brain energy and neurotransmitter support.

Why These Work Best Together

• B12 fuels your cells for sustained energy

• MICC turns fat into usable energy efficiently

• Glutathione protects cells from oxidative stress

• NAD+ powers mitochondria for consistent stamina

Together, they provide a full-spectrum approach: cellular fuel, metabolic support, detoxification, and mitochondrial efficiency. Your body gets the tools it needs to maintain energy, focus, and performance while transforming.

Energy and Weight Loss Can Coexist

Fatigue doesn’t have to be part of your GLP-1 journey. With the right combination of vitamins, amino acids, and mitochondrial support, your metabolism can stay efficient, your brain can stay sharp, and your energy can keep pace with your goals.

Key Takeaways

• GLP-1 therapies can cause temporary fatigue or brain fog due to rapid metabolic shifts.

• Targeted support with B12, MICC, Glutathione, and NAD+ restores energy at the cellular level.

• A combined approach addresses metabolism, detox, and cognitive clarity — so your weight loss doesn’t come at the cost of your vitality.

With Flow Wellness, you can lose weight, stay energized, and feel your best all at once.

Flow Wellness
Where science meets vitality — head to toe, cell by cell.

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